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Hematologic Toxicity: Monitor hemoglobin or hematocrit in patients with any signs or symptoms of anemia.

Avoid use of NSAIDs in women at about 30 weeks gestation and later in pregnancy due to the risks of oligohydramnios/fetal renal dysfunction and premature closure of the fetal ductus arteriosus.

Fetal Toxicity: Limit use of NSAIDs, including CELEBREX, between about 20 to 30 weeks in pregnancy due to the risk of oligohydramnios/fetal renal dysfunction.

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Discontinue and evaluate clinically.

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Serious Skin Reactions: Discontinue CELEBREX at first appearance of skin rash or other signs of hypersensitivity.Monitor patients with preexisting asthma (without aspirin sensitivity). Exacerbation of Asthma Related to Aspirin Sensitivity: CELEBREX is contraindicated in patients with aspirin-sensitive asthma.Anaphylactic Reactions: Seek emergency help if an anaphylactic reaction occurs.Avoid use of CELEBREX in patients with advanced renal disease unless benefits are expected to outweigh risk of worsening renal function. Renal Toxicity: Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia.

Heart Failure and Edema: Avoid use of CELEBREX in patients with severe heart failure unless benefits are expected to outweigh risk of worsening heart failure.Hypertension: Patients taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs.Discontinue if abnormal liver tests persist or worsen or if clinical signs and symptoms of liver disease develop. Hepatotoxicity: Inform patients of warning signs and symptoms of hepatotoxicity.